Effects of intravenous immunoglobulin treatment in dementia in consequent of cerebral microangiopathy

Effects of intravenous immunoglobulin treatment in dementia in consequent of cerebral microangiopathy

To evaluate the efficiency of intravenous immunoglobulin (IVIG) we examined 12 patients with the dementia-symptoms after stroke in consequence of cerebral microagiopathy. The patients were divided in of 8, of the same age and sex.

Both groups received the common cardiovascular treatment including 100-120 gr of peracetam for one year. One group was administered additionally a complementary monthly dose of IVIG 0,2 g/Kgr/body weigh for the duration of the study.

All patients underwent a clinical and neurophysiological examination (EEG, visual and auditory evoked response) cognitive-function by mini-mental state examination (MMSE) at the beginning and at the end at the treatment.

The comparison of the results of all tests before and after the treatment has shown a significant improvement in the group of patients with the additional treatment with the IVIG.

This lead us to believe that the immunomodulate function of IVIG is particularly beneficial in patients with dementia signs after cerebral microagiopathy and allows us for the hypothesis that there may be a disturbance in the immune system of these patients.

Abstract published in abstract book of 10^th BIENNIAL CONGRESS OF IEPG, 1998

Paper presented at the 10^th BIENNIAL CONGRESS of I PEG, Milan, Italy, November 20-22, 1998.