Αν και θεωρείται σχετικά σπάνιο, εντούτοις στη Βιονευρολογική έχουμε διαπιστώσει ότι το σύνδρομο της ορθοστατικής υπότασης εμφανίζεται αρκετά συχνά, ιδιαίτερα σε άτομα τα οποία πάσχουν από αυτοάνοσα νοσήματα
Σε άτομα τα οποία έχουν μια προδιάθεση για αυτοάνοσα νοσήματα, η ορθοστατική υπόταση κατά κύριο λόγο συμβαδίζει με δυο χαρακτηριστικές καταστάσεις· η μια είναι μια προδιάθεση για λοιμώξεις, ενώ ταυτόχρονα παρουσιάζονται και έντονες διαταραχές πανικού
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