The effects of dexamethason and intravenous IgG in acute states of primary central nervous system Lymphoma (PCNSL)

The effects of dexamethason and intravenous IgG in acute states of primary central nervous system Lymphoma  (PCNSL)

Kountouris Dimitris Center for Neurological Diagnosis, Athens, Greece

Background: The beneficial effects of cortizone in PCNSL have been widely known for a long time. Recent clinical studies suggest that intravenous immunoglobulin (IVIG) among its immunomodulatory and antimicrobial effects, improve the outcome of severely PCNSL in acute phase.

Method and Material: Two patients suffering from PCNSL were examined clinically, neurologically, neurophysiologically and neuroradiologically during the acute phase of the disease and later, year per year, for a period of 5 years. During this period they were receiving dexamethason for 3 months and IVIG for 3 years.

Results: In both cases the results of the treatment were significantly satisfactory. The clinical condition was improved besides the results of the other examinations. It is remarkable that this improvement remain stable for the following two years.

Conclusion: Dexamathason and IVIG is preferable in the treatment of the acute phase of PCNSL and these medicines have beneficial effect in the follow up of the patients.

Abstract published in abstract book of the 3rd International Conference on Acoustic Neurinoma and other CPA Tumors. Paper presented at the 3rd International Conference on Acoustic Neurinoma and other CPA Tumors, Italy, Rome, June 12-17, 1999.